Synthetic opioids, including fentanyl and fentanyl analogs, are quickly becoming the most common high hazard response. There are many ways that the overall risk can be managed. First, information is provided to assist in recognizing and understanding the threat. This is critical when determining the appropriate response. Example operational response protocols are provided for communications, protection, decontamination, detection, and medical countermeasures. These simple response protocols will assist responders in safely and effectively responding to this high hazard threat. This app is intended for emergency response personnel including law enforcement, fire, hazardous materials, emergency medical services, and public health who may respond to incidents involving synthetic opioids.